Warning:

To disseminate potentially life saving information in a timely fashion, not all theories, data, 
treatment ideas, proposals, prevention methods have been fully fact checked nor are they sanctioned
by me or the FDA.  The data seems reasonable and sound but is not meant to be medical advice.  
Please defer any off-label treatment to your treating physician.

***NOT FACT CHECKED***

In the last 3–5 days, a mountain of anecdotal evidence has come out of NYC, Italy, Spain, etc. about COVID-19 and characteristics of patients who get seriously ill. It’s not only piling up but now leading to a general field-level consensus backed up by a few previously little-known studies that we’ve had it all wrong the whole time. Well, a few had some things eerily correct (cough Trump cough), especially with Hydroxychloroquine with Azithromicin, but we’ll get to that in a minute.

There is

 no ‘pneumonia’ nor ARDS. At least not the ARDS with established treatment protocols and procedures we’re familiar with. Ventilators are not only the wrong solution, but high pressure intubation can actually wind up causing more damage than without, not to mention complications from tracheal scarring and ulcers given the duration of intubation often required… They may still have a use in the immediate future for patients too far to bring back with this newfound knowledge, but moving forward a new treatment protocol needs to be established so we stop treating patients for the wrong disease.

The past 48 hours or so have seen a huge revelation: COVID-19 causes prolonged and progressive hypoxia (starving your body of oxygen) by binding to the heme groups in hemoglobin in your red blood cells. People are simply desaturating (losing o2 in their blood), and that’s what eventually leads to organ failures that kill them, not any form of ARDS or pneumonia. All the damage to the lungs you see in CT scans are from the release of oxidative iron from the hemes, this overwhelms the natural defenses against pulmonary oxidative stress and causes that nice, always-bilateral ground glass opacity in the lungs. Patients returning for re-hospitalization days or weeks after recovery suffering from apparent delayed post-hypoxic leukoencephalopathy strengthen the notion COVID-19 patients are suffering from hypoxia despite no signs of respiratory ‘tire out’ or fatigue.

Here’s the breakdown of the whole process, including some ELI5-level cliff notes. Much has been simplified just to keep it digestible and layman-friendly.

Your red blood cells carry oxygen from your lungs to all your organs and the rest of your body. Red blood cells can do this thanks to hemoglobin, which is a protein consisting of four “hemes”. Hemes have a special kind of iron ion, which is normally quite toxic in its free form, locked away in its center with a porphyrin acting as it’s ‘container’. In this way, the iron ion can be ‘caged’ and carried around safely by the hemoglobin, but used to bind to oxygen when it gets to your lungs.

When the red blood cell gets to the alveoli, or the little sacs in your lungs where all the gas exchange happens, that special little iron ion can flip between FE2+ and FE3+ states with electron exchange and bond to some oxygen, then it goes off on its little merry way to deliver o2 elsewhere.

***NOT FACT CHECKED***

Here’s where COVID-19 comes in. Its glycoproteins bond to the heme, and in doing so that special and toxic oxidative iron ion is “disassociated” (released). It’s basically let out of the cage and now freely roaming around on its own. This is bad for two reasons:

1) Without the iron ion, hemoglobin can no longer bind to oxygen. Once all the hemoglobin is impaired, the red blood cell is essentially turned into a Freightliner truck cab with no trailer and no ability to store its cargo.. it is useless and just running around with COVID-19 virus attached to its porphyrin. All these useless trucks running around not delivering oxygen is what starts to lead to desaturation, or watching the patient’s spo2 levels drop. It is INCORRECT to assume traditional ARDS and in doing so, you’re treating the WRONG DISEASE. Think of it a lot like carbon monoxide poisoning, in which CO is bound to the hemoglobin, making it unable to carry oxygen. In those cases, ventilators aren’t treating the root cause; the patient’s lungs aren’t ‘tiring out’, they’re pumping just fine. The red blood cells just can’t carry o2, end of story. Only in this case, unlike CO poisoning in which eventually the CO can break off, the affected hemoglobin is permanently stripped of its ability to carry o2 because it has lost its iron ion. The body compensates for this lack of o2 carrying capacity and deliveries by having your kidneys release hormones like erythropoietin, which tell your bone marrow factories to ramp up production on new red blood cells with freshly made and fully functioning hemoglobin. This is the reason you find elevated hemoglobin and decreased blood oxygen saturation as one of the 3 primary indicators of whether the shit is about to hit the fan for a particular patient or not.

2) That little iron ion, along with millions of its friends released from other hemes, are now floating through your blood freely. As I mentioned before, this type of iron ion is highly reactive and causes oxidative damage. It turns out that this happens to a limited extent naturally in our bodies and we have cleanup & defense mechanisms to keep the balance. The lungs, in particular, have 3 primary defenses to maintain “iron homeostasis”, 2 of which are in the alveoli, those little sacs in your lungs we talked about earlier. The first of the two are little macrophages that roam around and scavenge up any free radicals like this oxidative iron. The second is a lining on the walls (called the epithelial surface) which has a thin layer of fluid packed with high levels of antioxidant molecules.. things like abscorbic acid (AKA Vitamin C) among others. Well, this is usually good enough for naturally occurring rogue iron ions but with COVID-19 running rampant your body is now basically like a progressive state letting out all the prisoners out of the prisons… it’s just too much iron and it begins to overwhelm your lungs’ countermeasures, and thus begins the process of pulmonary oxidative stress. This leads to damage and inflammation, which leads to all that nasty stuff and damage you see in CT scans of COVID-19 patient lungs. Ever noticed how it’s always bilateral? (both lungs at the same time) Pneumonia rarely ever does that, but COVID-19 does… EVERY. SINGLE. TIME.

— — — — — — — — — — — — –

***NOT FACT CHECKED***

Once your body is now running out of control, with all your oxygen trucks running around without any freight, and tons of this toxic form of iron floating around in your bloodstream, other defenses kick in. While your lungs are busy with all this oxidative stress they can’t handle, and your organs are being starved of o2 without their constant stream of deliveries from red blood cell’s hemoglobin, and your liver is attempting to do its best to remove the iron and store it in its ‘iron vault’. Only its getting overwhelmed too. It’s starved for oxygen and fighting a losing battle from all your hemoglobin letting its iron free, and starts crying out “help, I’m taking damage!” by releasing an enzyme called alanine aminotransferase (ALT). BOOM, there is your second of 3 primary indicators of whether the shit is about to hit the fan for a particular patient or not.

Eventually, if the patient’s immune system doesn’t fight off the virus in time before their blood oxygen saturation drops too low, ventilator or no ventilator, organs start shutting down. No fuel, no work. The only way to even try to keep them going is max oxygen, even a hyperbaric chamber if one is available on 100% oxygen at multiple atmospheres of pressure, just to give what’s left of their functioning hemoglobin a chance to carry enough o2 to the organs and keep them alive. Yeah we don’t have nearly enough of those chambers, so some fresh red blood cells with normal hemoglobin in the form of a transfusion will have to do.

The core point being, treating patients with the iron ions stripped from their hemoglobin (rendering it abnormally nonfunctional) with ventilator intubation is futile, unless you’re just hoping the patient’s immune system will work its magic in time. The root of the illness needs to be addressed.

Best case scenario? Treatment regimen early, before symptoms progress too far. Hydroxychloroquine (more on that in a minute, I promise) with Azithromicin has shown fantastic, albeit critics keep mentioning ‘anecdotal’ to describe the mountain, promise and I’ll explain why it does so well next. But forget straight-up plasma with antibodies, that might work early but if the patient is too far gone they’ll need more. They’ll need all the blood: antibodies and red blood cells. No help in sending over a detachment of ammunition to a soldier already unconscious and bleeding out on the battlefield, you need to send that ammo along with some hemoglobin-stimulant-magic so that he can wake up and fire those shots at the enemy.

The story with Hydroxychloroquine

All that hilariously misguided and counterproductive criticism the media piled on chloroquine (purely for political reasons) as a viable treatment will now go down as the biggest Fake News blunder to rule them all. The media actively engaged their activism to fight ‘bad orange man’ at the cost of thousands of lives. Shame on them.

How does chloroquine work? Same way as it does for malaria. You see, malaria is this little parasite that enters the red blood cells and starts eating hemoglobin as its food source. The reason chloroquine works for malaria is the same reason it works for COVID-19 — while not fully understood, it is suspected to bind to DNA and interfere with the ability to work magic on hemoglobin. The same mechanism that stops malaria from getting its hands on hemoglobin and gobbling it up seems to do the same to COVID-19 (essentially little snippets of DNA in an envelope) from binding to it. On top of that, Hydroxychloroquine (an advanced descendant of regular old chloroquine) lowers the pH which can interfere with the replication of the virus. Again, while the full details are not known, the entire premise of this potentially ‘game changing’ treatment is to prevent hemoglobin from being interfered with, whether due to malaria or COVID-19.

***NOT FACT CHECKED***

No longer can the media and armchair pseudo-physicians sit in their little ivory towers, proclaiming “DUR so stoopid, malaria is bacteria, COVID-19 is virus, anti-bacteria drug no work on virus!”. They never got the memo that a drug doesn’t need to directly act on the pathogen to be effective. Sometimes it’s enough just to stop it from doing what it does to hemoglobin, regardless of the means it uses to do so.

Anyway, enough of the rant. What’s the end result here? First, the ventilator emergency needs to be re-examined. If you’re putting a patient on a ventilator because they’re going into a coma and need mechanical breathing to stay alive, okay we get it. Give ’em time for their immune systems to pull through. But if they’re conscious, alert, compliant — keep them on O2. Max it if you have to. If you HAVE to inevitably ventilate, do it at low pressure but max O2. Don’t tear up their lungs with max PEEP, you’re doing more harm to the patient because you’re treating the wrong disease.

Ideally, some form of treatment needs to happen to:

1. Inhibit viral growth and replication. Here plays CHQ+ZPAK+ZINC or other retroviral therapies being studies. Less virus, less hemoglobin losing its iron, less severity and damage.
2. Therapies used for anyone with abnormal hemoglobin or malfunctioning red blood cells. Blood transfusions. Whatever, I don’t know the full breadth and scope because I’m not a physician. But think along those lines, and treat the real disease. If you’re thinking about giving them plasma with antibodies, maybe if they’re already in bad shape think again and give them BLOOD with antibodies, or at least blood followed by plasma with antibodies.
3. Now that we know more about how this virus works and affects our bodies, a whole range of options should open up.
4. Don’t trust China. China is ASSHOE. (disclaimer: not talking about the people, just talking about the regime). They covered this up and have caused all kinds of death and carnage, both literal and economic. The ripples of this pandemic will be felt for decades.

XXXX(author’s name retracted for privacy.

_________________

FDA approves emergency use of malaria pill for COVID-19 treatment

So why is this such big news?   Doctors use FDA approved medications (such as Chloroquine and Hydroxychloroquine) off -label all the time.  I guess the liability, insurance reimbursement, and widespread acceptance is supported by FDA Approval.  We really need FDA approved TESTING and need it NOW.

 

Vitamin C/Ascorbic Acid

There is evidence that IV infusion may be of benefit.

 

Steroids

There is a marked inflammatory response with Covid Infection.   It is certainly reasonable to blunt this response with Steroids and perhaps NSAID.

 

 

Vaccination

We never came up with a MERS or SARS vaccine and have never created a Corona Vaccine.  Can we do it now and how long will it take?  Some suggest that it can be up to 2 years.  

Recent Insight from Treating Physician in New Orleans

 

Prevention is the best treatment.

See these excellent tips to prevent illness. To be completely safe, avoid contact with everyone as much as possible. This is transmitted person to person. Someone does not have to sneeze or cough on you. Just talking in close proximity can disseminate the disease. Definitely, avoid contact with ill individuals, avoid exposure to respiratory secretions. Have suspected individuals wear a mask.

One would think that there would have been a protective effect of hajibs and Arab women would be less affected as they routinely cover their mouth. Don’t touch your nose/mouth. Wash hands in hot water and soap frequently. If suspected of infection, seek medical attention ASAP. Isolate yourself from others and identify all potential contacts for isolation. Most infections are mild, but avail youself of medical attention and supportive measures.

The government should research the feasibility and effectivity for plasma donation and if a viable option rapidly coordinate efforts for donation of plasma from those that have recovered from the disease internationally. One donor can potentially treat three patients. The naturally produced antibodies that are in the plasma can potentially confer immunity to at risk or infected individuals and reduce the morbidity and mortality from this virus.

Realistically, the answer in the short term will be collaboration and Plasma therapy. In short, plasma with antibodies from patients that have recovered can be infused in infected patients to fight the virus. Contact us for more information… [email protected]

We have about 200,000 ventilators, likely will need 1,000,000. 

The drug rendesivir has shown promise in treating the Corona Virus.

Early data suggests that Chloroquine and Hydroxychloroquine may be an effective treatment.  These medications have been used for years to treat Lupus and Rheumatoid Arthritis and prophylaxis for Malaria.   If you need this medicine, contact us, we may be able to help.   As a society we need to reach out to those with stockpiles and patients that have reserves of medications and can contribute to the stocks.

A vaccine is on the horizon… but not available realistically for almost a year.

— Terms approved to proceed with collaborative effort with international consortium

MIRAMAR, Fla., Feb. 27, 2020 (GLOBE NEWSWIRE) — Generex Biotechnology Corporation (www.generex.com) (GNBT) (http://www.otcmarkets.com/stock/GNBT/quote) today announced that the company has received a contract from the China Technology Exchange, Beijing Zhonghua Investment Fund Management Co., LTD., Biology Institute of Shandong Academy of Sciences and Sinotek-Advocates International Industry Development (Shenzhen) Co., LTD. The terms of the contract, which have been agreed to in writing by both parties, include an upfront payment of $1 million to initiate the project work in the United States, a $5 million licensing fee for the Ii-Key technology, payment by the Chinese consortium for all costs and expenses related to the development of a COVID-19 vaccine, and a 20% royalty on each dose of vaccine produced. read more

How to Kill the corona virus

Those claims are true according to the Center for Biocide Chemistries. They’ve created a list of more than 100 ready to use, dilatable and wipeable biocidal products that the EPA has approved as effective at killing viruses like the coronavirus.

Here is the list:

1. 128 Disinfectant

2. 128 E-Fecticide

3. 14 plus antibacterial all-purpose cleaner

4. 20 neutral disinfectant cleaner

5. 256 Century Q

6. 3M Disinfectant Cleaner RCT Concentrate

7. 3M MBS Disinfectant Cleaner Concentrate

8. 3M MBS Disinfectant Cleaner Fresh Scent Concentrate

9. 3M Neutral Quat Disinfectant Cleaner Concentrate

10. 3M Quat Disinfectant Cleaner Concentrate

11. A-456 ii disinfectant cleaner

12. ACS Tornado 1 – one-step disinfectant American Chemical Systems 6836-75-86408

13. All Purpose Virex

14. All Purpose Virex Diversey, Inc. 1839-83-70627

15. Array Non-Acid Restroom Cleaner & Disinfectant

16. Avert Sporicidal Disinfectant Cleaner

17. Bleach disinfectant cleaner Ecolab Inc

18. Boost 3200 CIP

19. Boost 3200

20. Boost surface treatment

21. Brighton Professional Hepastat 256

22. Buckeye Eco Neutral Disinfectant

23. Buckeye Eco One-Step Disinfectant-Deodorizer-Cleaner

24. Buckeye Sanicare Lemon Quat

25. Buckeye Sanicare Mint Quat

26. Buckeye Sanicare Pine Quat

27. Buckeye Sanicare Quat 128

28. Buckeye Sanicare Quat 256

29. Buckeye Sani-Q2 B

30. Buckeye Terminator

31. Centraz San Sol 10

32. Classic Whirlpool Disinfectant and Cleaner

33. Clean Quick broad range quaternary sanitizer
34. Clear Gear Sports Spray-On

35. Clicksan disinfectant/sanitizer Ecolab Inc/kay chemical co. 6836-305-5389

36. Clorox 4 In One Disinfecting Spray

37. Clorox Clean-Up Cleaner + Bleach

38. Clorox Commercial Solutions Clorox 4-in-One Disinfectant & Sanitizer

39. Clorox Commercial Solutions Clorox Clean-Up Disinfectant Cleaner with Bleach

40. Clorox Commercial Solutions Clorox Disinfecting Bathroom Cleaner

41. Clorox Commercial Solutions Clorox Disinfecting Biostain & Odor Remover

42. Clorox Commercial Solutions Clorox Disinfecting Spray

43. Clorox Commercial Solutions Hydrogen Peroxide Cleaner Disinfectant

44. Clorox Commercial Solutions Tilex Soap Scum Remover

45. Clorox Commercial Solutions toilet Bowl Cleaner with Bleach

46. Clorox Disinfecting Bathroom Cleaner

47. Clorox Healthcare Bleach Germicidal Cleaner Spray

48. Clorox Healthcare Fuzion cleaner

49. Clorox Healthcare Hydrogen Peroxide Cleaner Disinfectant

50. Clorox Multi-Surface Cleaner + Bleach

51. Clorox Pet Solutions Advanced Formula Disinfecting Stain & Odor Remover

52. Clorox Scentiva Bathroom Disinfectant Foamer

53. Clorox Scentiva Bathroom Disinfecting Foam Cleaner

54. Clorox Toilet Bowl Cleaner Clinging Bleach Gel

55. Clorox Toilet Bowl Cleaner with Bleach

56. Cloroxpro Clorox Total 360 Disinfecting Cleaner

57. Coastwide Professional Hepastat 256

58. Confidence Plus 2

59. Cosa Oxonia Active

60. Don-O-Mite

61. Extra Spearmint Germicidal Detergent and Deodorant

62. Food contact Quat sanitizer

63. Foster First Defense

64. G-5 Sanitizer

65. GASCO Quaternary Sanitizer

66. Germ-A-Cide 64

67. Germicidal Cleaner and Disinfectant Gordon Food Service

68. Kay surface sanitizer

69. Kayquat II

70. Klercide 70/30

71. Lemon Cleaner U S Chemical

72. Lemon Disinfectant American Chemical Systems

73. Lysol bleach mold and mildew remover

74. Lysol bleach multi-purpose cleaner

75. Lysol cling & fresh toilet bowl cleaner

76. Lysol Disinfectant Max Cover Mist

77. Lysol disinfectant spray

78. Lysol lime & rust toilet bowl cleaner

79. Lysol power plus toilet bowl cleaner

80. Lysol power toilet bowl cleaner

81. MAPS- 1 RTU

82. Medline Micro-Kill NQ5

83. Microban 24

84. Microban 24 hour Bathroom Cleaner

85. Microban 24 Hour Multi-Purpose Cleaner
86. Mixmate Germicidal Cleaner

87. Mixmate Microtech Non-Acid Restroom Cleaner & Disinfectant

88. Mixmate Non-Acid Restroom Cleaner & Disinfectant

89. Multi-purpose neutral ph germicidal detergent

90. Multi-quat Mega-1 Intercon

91. Neutral disinfectant cleaner Ecolab Inc

92. Neutral Disinfectant Cleaner Gordon Food Service

93. Oasis 499 HBV disinfectant

94. One-Step Disinfectant Cleaner

95. OPI Spa Complete

96. OXIVIR

97. OXIVIR 1

98. OXIVIR Tb

99. Oxonia Active

100. Oxycide daily disinfectant cleaner

101. Oxy-team disinfectant cleaner

102. Performex

103. Peroxide disinfectant and glass cleaner RTU Ecolab Inc

104. Peroxide multi-surface cleaner and disinfectant

105. Pine Cleaner Disinfectant

106. Professional Lysol disinfectant spray

107. Purell Food Processing Surface Sanitizer

108. Purell Foodservice Surface Sanitizer

109. Purell Healthcare Surface Disinfectant

110. Purell Multi-Surface Disinfectant

111. Purell Professional Surface Disinfectant

112. Q.T. 3

113. Q.T. Plus

114. Quaternary disinfectant cleaner

115. RTU Disinfectant Cleaner

116. Sani quad food service sanitizer

117. Sani-24 Germicidal Spray

118. Sanicare TBX

119. Sanifect Plus 1

120. Sanifect Plus 2 Fresh N Clean

121. Sani-Hypercide Germicidal Spray

122. Sani-Hypercide Germicidal Spray

123. Sani-Prime Germicidal Spray

124. Sani-Spritz Spray Nyco Products Company

125. Sanitizer/commercial sanitizer Ecolab Inc

126. SC-RTU Disinfectant cleaner

127. Simple Green D Pro 5

128. Stepan Spray Disinfectant Concentrate

129. Super San food service sanitizer

130. Tb disinfectant cleaner ready-to-use

131. TB Quat

132. Tec-quat 128

133. Triple Play Ecolab Inc

134. United 255 Disinfect Plus

135. Virasept

136. Virex

137. VIREX II / 256

138. Wide Range II Non-Acid Disinfectant Washroom Cleaner Concentrate

139. X-Ray Apron Cleaner Disinfectant Bioxco LLC / Mediredi

 

Several drugs found effective in clinical trials

Rendesivir, chloroquine phosphate, hydroxychloroquine and fapilavir, have been screened and have shown good clinical efficacy in treating the novel coronavirus, according to Zhang Xinmin, director of the China National Center for Biotechnology Development under the Ministry of Science and Technology. Rendesivir, a new antiviral drug by U.S. company Gilead that reportedly cured a patient in the U.S., has shown good inhibiting effects on the virus and quite a high level of safety in vitro experiments, Zhang said.